Many people on the left are concerned about Big Business. They worry that individual expression and liberty will get trampled by a corporate bureacuracy intent on self preservation and growth. Many people on the right are concerned about the behavior of Big Government. They worry that indivual expression and liberty will get trampled by government bureacracy intent on self preservation and growth. Entrepreneurs and artists are or should be concerned about both.
On the flip side, there is a lot of value to scale. For example, the quality of produce in my neighborhood has increased dramatically since Whole Foods arrived. Neither cars nor computers would not be available to most people if there were not big corporations and mass markets producing them. It took the might of the US government to stop both Nazi Germany and Soviet Russia from spreading misery and death around the world.
In general I am biased in favor of letting individuals negotiate differences among themselves. I am not at all certain that government enforcement of contracts and payments serves anyone. More on this later. In the interim, read this post by Jeff Jarvis about the problems when companies grow. He is responding to this post by Fred Wilson asking whether Google is becoming AOL.